Irresistible Bubble Up Pizza Casserole

Category: Dinner Ideas That Actually Work

Cook ground meat with seasonings and sauce, stir in biscuit chunks, layer it all in a casserole dish with mozzarella and toppings like pepperoni, then bake until it’s golden and delicious.
Clare Recipes
Updated on Thu, 13 Mar 2025 12:44:52 GMT
Cheesy Biscuit Pizza Casserole Save
Cheesy Biscuit Pizza Casserole | recipesclare.com

Transform your pizza night with this irresistible bubble up pizza casserole. The magic happens when refrigerated biscuits puff up between layers of seasoned meat sauce and melted cheese, creating a comforting dish that delivers all your favorite pizza flavors. This family-approved casserole comes together in minutes but tastes like you spent hours in the kitchen.

This recipe has become legendary at potlucks and team dinners. The combination of tender biscuits, savory meat sauce, and melted cheese creates such restaurant-quality results that guests are always shocked to learn how easily it comes together.

Essential Ingredients

  • Ground beef - Choose 85/15 lean ground beef for ideal flavor and texture. Ground Italian sausage offers a delicious variation.
  • Refrigerated biscuits - Large-style biscuits quartered create the perfect doughy texture throughout.
  • Pizza sauce - Quality jarred sauce streamlines prep time. Enhanced with herbs or red pepper flakes if desired.
  • Cheese blend - Fresh-grated mozzarella provides stretch while sharp cheddar adds depth.
  • Toppings - Classic pepperoni works beautifully, but any pizza toppings can be incorporated.
Bubble Up Pizza Casserole Homemade Save
Bubble Up Pizza Casserole Homemade | recipesclare.com

Essential Techniques

Layer the flavors:
Season the meat while browning for depth throughout the dish.
Perfect the beef:
Brown just until cooked through to maintain moisture.
Size matters:
Quarter biscuits evenly - proper sizing ensures ideal texture.
Coat thoroughly:
Each biscuit piece needs sauce coverage for even baking.
Strategic assembly:
Careful layering distributes ingredients evenly.
Monitor edges:
Cover with foil if browning too quickly.
Rest period:
Allow 5-10 minutes rest time for clean serving.

This recipe emerged from a happy accident when pizza dough wasn't available. The resulting casserole impressed even dedicated pizza enthusiasts. It's now a cherished family tradition, with kids eagerly helping quarter biscuits and arrange toppings.

Perfect Pairings

Balance the rich casserole with a crisp Italian-dressed salad. Garlic breadsticks make excellent sauce-scooping companions. Fresh vegetable crudités with ranch dressing complete the meal perfectly.

Creative Variations

Consider a creamy chicken version with Alfredo sauce, or load it up supreme-style with sautéed vegetables. Spice lovers can incorporate hot sausage, pepper jack cheese, and fresh jalapeños.

Storage Guide

Refrigerate leftovers up to three days. Reheat individual portions in the microwave or warm the whole casserole, covered, at 325°F. Avoid freezing as it affects the biscuit texture.

Bubble Up Pizza Casserole Recipe Save
Bubble Up Pizza Casserole Recipe | recipesclare.com

This versatile casserole has proven its worth countless times, from weeknight dinners to outdoor cookouts. The combination of cheesy topping and tender biscuit base creates an irresistible comfort food that consistently delivers satisfaction.

Recipe FAQs

→ Is it okay to make this ahead of time?
Sure, just prep the meat sauce in advance. But wait to add the biscuit chunks until you’re ready to bake so they don’t get soggy.
→ Can I use something other than biscuit dough?
Yep! Crescent roll or pizza dough will do just fine. The texture changes a little, but they’re still delicious.
→ Is this dish freezer-friendly?
Not really. Biscuits don’t freeze or reheat well here. Leftovers, though, will keep in the fridge for a couple of days.
→ How can I tell when it’s fully baked?
Check that the biscuits are puffy and golden on top. Stick a knife in the middle—there shouldn’t be raw dough.
→ Can I make a vegetarian version?
Definitely! Skip the meat and pack it full of vegetables like bell peppers, mushrooms, and onions for a hearty veggie option.

Cheesy Biscuit Pizza Bake

A creative and fun take on pizza night with flaky biscuit dough rising in a savory meat sauce, layered with gooey cheese and your favorite toppings. Quick, family-friendly, and so easy!

Preparation Time
15 min
Cooking Time
30 min
Total Time
45 min

Category: Main Dishes

Skill Level: Beginner

Cuisine Type: American

Makes: 6 Serves

Dietary Preferences: ~

Ingredients

→ For the Casserole

01 1 small onion, chopped into tiny pieces
02 1 pound of lean ground beef (or you can swap for turkey or sausage)
03 2 garlic cloves, finely chopped
04 1 can (15 ounces) of pizza sauce
05 1 teaspoon of Italian seasoning
06 1/2 teaspoon of garlic powder
07 Salt and pepper, adjusted to your taste
08 1 package (12 ounces) of biscuit dough (such as Pillsbury Grands), cut into quarters
09 2 cups of mozzarella cheese, shredded
10 1/2 cup of pepperoni slices
11 1 cup of cheddar cheese, shredded (optional for a cheesier dish)
12 Cooking spray for greasing your baking dish

Steps

Step 01

Turn your oven on and set it to 375°F (190°C). Lightly coat a 9x13 baking dish with cooking spray.

Step 02

Warm up a large skillet over medium heat. Cook the ground beef, onion, and garlic together, stirring often, until the meat is browned and no longer pink. Toss out any extra grease from the pan.

Step 03

Mix the pizza sauce, garlic powder, Italian seasoning, and a pinch of salt and pepper into the meat mixture. Stir well so everything combines nicely.

Step 04

Gently stir the quartered biscuit pieces into the mixture so they’re coated evenly in the sauce.

Step 05

Spoon half of the meat and biscuit mixture into the prepared baking dish. Add half the mozzarella, cheddar, and pepperoni on top. Repeat these layers with the rest of the ingredients.

Step 06

Pop the dish into the oven and bake for 25 to 30 minutes. It’s done when the biscuits are golden, puffed, and the cheese is perfectly melted.

Step 07

Take the dish out of the oven and let it sit for 5 minutes before slicing it up. This makes serving easier.

Helpful Notes

  1. Feel free to add other toppings you love, like mushrooms, ham, olives, or bell peppers, for a personal twist.

Required Tools

  • A 9x13-inch dish for baking
  • A big skillet for cooking
  • A knife to chop ingredients
  • A cutting board

Allergen Info

Check each ingredient for potential allergens and seek medical advice if unsure.
  • Made with dairy (cheese)
  • Includes gluten (biscuit dough)