
Transform your pizza night with this irresistible bubble up pizza casserole. The magic happens when refrigerated biscuits puff up between layers of seasoned meat sauce and melted cheese, creating a comforting dish that delivers all your favorite pizza flavors. This family-approved casserole comes together in minutes but tastes like you spent hours in the kitchen.
This recipe has become legendary at potlucks and team dinners. The combination of tender biscuits, savory meat sauce, and melted cheese creates such restaurant-quality results that guests are always shocked to learn how easily it comes together.
Essential Ingredients
- Ground beef - Choose 85/15 lean ground beef for ideal flavor and texture. Ground Italian sausage offers a delicious variation.
- Refrigerated biscuits - Large-style biscuits quartered create the perfect doughy texture throughout.
- Pizza sauce - Quality jarred sauce streamlines prep time. Enhanced with herbs or red pepper flakes if desired.
- Cheese blend - Fresh-grated mozzarella provides stretch while sharp cheddar adds depth.
- Toppings - Classic pepperoni works beautifully, but any pizza toppings can be incorporated.

Essential Techniques
- Layer the flavors:
- Season the meat while browning for depth throughout the dish.
- Perfect the beef:
- Brown just until cooked through to maintain moisture.
- Size matters:
- Quarter biscuits evenly - proper sizing ensures ideal texture.
- Coat thoroughly:
- Each biscuit piece needs sauce coverage for even baking.
- Strategic assembly:
- Careful layering distributes ingredients evenly.
- Monitor edges:
- Cover with foil if browning too quickly.
- Rest period:
- Allow 5-10 minutes rest time for clean serving.
This recipe emerged from a happy accident when pizza dough wasn't available. The resulting casserole impressed even dedicated pizza enthusiasts. It's now a cherished family tradition, with kids eagerly helping quarter biscuits and arrange toppings.
Perfect Pairings
Balance the rich casserole with a crisp Italian-dressed salad. Garlic breadsticks make excellent sauce-scooping companions. Fresh vegetable crudités with ranch dressing complete the meal perfectly.
Creative Variations
Consider a creamy chicken version with Alfredo sauce, or load it up supreme-style with sautéed vegetables. Spice lovers can incorporate hot sausage, pepper jack cheese, and fresh jalapeños.
Storage Guide
Refrigerate leftovers up to three days. Reheat individual portions in the microwave or warm the whole casserole, covered, at 325°F. Avoid freezing as it affects the biscuit texture.

This versatile casserole has proven its worth countless times, from weeknight dinners to outdoor cookouts. The combination of cheesy topping and tender biscuit base creates an irresistible comfort food that consistently delivers satisfaction.
Frequently Asked Questions
- → Is it okay to make this ahead of time?
- Sure, just prep the meat sauce in advance. But wait to add the biscuit chunks until you’re ready to bake so they don’t get soggy.
- → Can I use something other than biscuit dough?
- Yep! Crescent roll or pizza dough will do just fine. The texture changes a little, but they’re still delicious.
- → Is this dish freezer-friendly?
- Not really. Biscuits don’t freeze or reheat well here. Leftovers, though, will keep in the fridge for a couple of days.
- → How can I tell when it’s fully baked?
- Check that the biscuits are puffy and golden on top. Stick a knife in the middle—there shouldn’t be raw dough.
- → Can I make a vegetarian version?
- Definitely! Skip the meat and pack it full of vegetables like bell peppers, mushrooms, and onions for a hearty veggie option.